Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50064599 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_157717 (CHEMBL763391) |
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Ki | 0.035±n/a nM |
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Citation | Han, Q; Chang, CH; Li, R; Ru, Y; Jadhav, PK; Lam, PY Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency. J Med Chem41:2019-28 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50064599 |
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n/a |
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Name | BDBM50064599 |
Synonyms: | (4R,5S,6S,7R)-1-(3-Amino-benzyl)-4,7-dibenzyl-5,6-dihydroxy-3-[3-(2H-pyrazol-3-yl)-benzyl]-[1,3]diazepan-2-one | CHEMBL60352 |
Type | Small organic molecule |
Emp. Form. | C36H37N5O3 |
Mol. Mass. | 587.7107 |
SMILES | Nc1cccc(CN2[C@H](Cc3ccccc3)[C@H](O)[C@@H](O)[C@@H](Cc3ccccc3)N(Cc3cccc(c3)-c3cc[nH]n3)C2=O)c1 |
Structure |
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