| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM175 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157717 (CHEMBL763391) |
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| Ki | 0.037±n/a nM |
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| Citation |  Han, Q; Chang, CH; Li, R; Ru, Y; Jadhav, PK; Lam, PY Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency. J Med Chem41:2019-28 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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| BDBM175 |
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| n/a |
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| Name | BDBM175 |
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| Synonyms: | (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis({[3-(2,2,2-trifluoroacetyl)phenyl]methyl})-1,3-diazepan-2-one | (4R,5S,6S,7R)-Hexahydro-5,6-dihydroxy-1,3-bis[[3-(trifluoroacetyl)phenyl]methyl]-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one | CHEMBL292631 | Cyclic Urea |
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| Type | n/a |
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| Emp. Form. | C37H32F6N2O5 |
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| Mol. Mass. | 698.6508 |
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| SMILES | O[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2cccc(c2)C(=O)C(F)(F)F)C(=O)N(Cc2cccc(c2)C(=O)C(F)(F)F)[C@@H]1Cc1ccccc1 |
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| Structure | 
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