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TargetOxytocin receptor
LigandBDBM50064709
Substrate/Competitorn/a
Meas. Tech.ChEMBL_149175 (CHEMBL762090)
Ki 3.4±n/a nM
Citation Bell, IMErb, JMFreidinger, RMGallicchio, SNGuare, JPGuidotti, MTHalpin, RAHobbs, DWHomnick, CFKuo, MSLis, EVMathre, DJMichelson, SRPawluczyk, JMPettibone, DJReiss, DRVickers, SWilliams, PDWoyden, CJ Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines. J Med Chem41:2146-63 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Oxytocin receptor
Name:Oxytocin receptor
Synonyms:OT-R | OXYR_RAT | Otr | Oxtr | Oxytocin
Type:Enzyme Catalytic Domain
Mol. Mass.:42889.28
Organism:RAT
Description:Oxytocin OXTR RAT::P70536
Residue:388
Sequence:
MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACV
LLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA
AAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWD
VNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGETS
VSKKSNSSTFVLSRRSSSQRSCSQPSSA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50064709
n/a
NameBDBM50064709
Synonyms:1-(1-{4-[1-(2-Ethyl-4,6-dimethyl-1-oxy-pyridin-3-ylmethyl)-piperidin-4-yloxy]-5-fluoro-2-methoxy-benzoyl}-piperidin-4-yl)-1,4-dihydro-benzo[d][1,3]oxazin-2-one | CHEMBL66985
TypeSmall organic molecule
Emp. Form.C36H43FN4O6
Mol. Mass.646.7482
SMILESCCc1c(CN2CCC(CC2)Oc2cc(OC)c(cc2F)C(=O)N2CCC(CC2)N2C(=O)OCc3ccccc23)c(C)cc(C)[n+]1[O-]
Structure
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