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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50064961
Substrate/Competitorn/a
Meas. Tech.ChEMBL_200965 (CHEMBL802053)
Ki 3.92±n/a nM
Citation Huang, YHammond, PSWhirrett, BRKuhner, RJWu, LChilders, SRMach, RH Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands. J Med Chem41:2361-70 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:Enzyme Catalytic Domain
Mol. Mass.:25124.85
Organism:Homo sapiens (Human)
Description:Q99720
Residue:223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50064961
n/a
NameBDBM50064961
Synonyms:CHEMBL77953 | N-(1-Benzyl-piperidin-4-yl)-2-(3-trifluoromethyl-phenyl)-acetamide
TypeSmall organic molecule
Emp. Form.C21H23F3N2O
Mol. Mass.376.4153
SMILESFC(F)(F)c1cccc(CC(=O)NC2CCN(Cc3ccccc3)CC2)c1
Structure
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