Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50064961 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_200965 (CHEMBL802053) |
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Ki | 3.92±n/a nM |
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Citation | Huang, Y; Hammond, PS; Whirrett, BR; Kuhner, RJ; Wu, L; Childers, SR; Mach, RH Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands. J Med Chem41:2361-70 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50064961 |
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n/a |
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Name | BDBM50064961 |
Synonyms: | CHEMBL77953 | N-(1-Benzyl-piperidin-4-yl)-2-(3-trifluoromethyl-phenyl)-acetamide |
Type | Small organic molecule |
Emp. Form. | C21H23F3N2O |
Mol. Mass. | 376.4153 |
SMILES | FC(F)(F)c1cccc(CC(=O)NC2CCN(Cc3ccccc3)CC2)c1 |
Structure |
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