Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50065078 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_157733 (CHEMBL765171) |
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Ki | 0.018±n/a nM |
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Citation | De Lucca, GV; Kim, UT; Liang, J; Cordova, B; Klabe, RM; Garber, S; Bacheler, LT; Lam, GN; Wright, MR; Logue, KA; Erickson-Viitanen, S; Ko, SS; Trainor, GL Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues. J Med Chem41:2411-23 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50065078 |
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n/a |
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Name | BDBM50065078 |
Synonyms: | (4R,5S,6S,7R)-1-(3-Amino-4-fluoro-benzyl)-4,7-dibenzyl-5,6-dihydroxy-3-(1H-indazol-5-ylmethyl)-[1,3]diazepan-2-one | CHEMBL420944 |
Type | Small organic molecule |
Emp. Form. | C34H34FN5O3 |
Mol. Mass. | 579.6639 |
SMILES | Nc1cc(CN2[C@H](Cc3ccccc3)[C@H](O)[C@@H](O)[C@@H](Cc3ccccc3)N(Cc3ccc4[nH]ncc4c3)C2=O)ccc1F |
Structure |
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