| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
|---|
| Ligand | BDBM50065089 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_157733 (CHEMBL765171) |
|---|
| Ki | 0.018±n/a nM |
|---|
| Citation |  De Lucca, GV; Kim, UT; Liang, J; Cordova, B; Klabe, RM; Garber, S; Bacheler, LT; Lam, GN; Wright, MR; Logue, KA; Erickson-Viitanen, S; Ko, SS; Trainor, GL Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues. J Med Chem41:2411-23 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gag-Pol polyprotein [489-587] |
|---|
| Name: | Gag-Pol polyprotein [489-587] |
|---|
| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 10781.16 |
|---|
| Organism: | Human immunodeficiency virus type 1 |
|---|
| Description: | P04585[489-587] |
|---|
| Residue: | 99 |
|---|
| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
|---|
| BDBM50065089 |
|---|
| n/a |
|---|
| Name | BDBM50065089 |
|---|
| Synonyms: | (4R,5R,6R)-Tetrahydro-1,3-bis[(3-benzamide oxime)-methyl]-5-hydroxy-4-(2-phenylethyl)-6-(phenylethyl)-2-(1H)-pyrimidinone | (4R,5R,6R)-tetrahydro-1,3-bis-](3-(N-Hydroxy-benzamidine)methyl]-5-hydroxy-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone | 3-[(6-Benzyl-5-hydroxy-2-oxo-4-phenethyl-tetrahydro-pyrimidin-1-yl)bis-(methyl-N-hydroxy-benzamidine)] | 3-[4-benzyl-3-(3-carbamoylbenzyl)-5-hydroxy-2-oxo-6-phenethyl-(4R,5R,6R)-hexahydro-1-pyrimidinylmethyl]N-hydroxy-benzamidine | CHEMBL284942 | Tetrahydropyrimidinone derivative |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H38N6O4 |
|---|
| Mol. Mass. | 606.714 |
|---|
| SMILES | ONC(=N)c1cccc(CN2[C@H](CCc3ccccc3)[C@@H](O)[C@@H](Cc3ccccc3)N(Cc3cccc(c3)C(=N)NO)C2=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
