Reaction Details |
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Target | Muscarinic acetylcholine receptor M1 |
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Ligand | BDBM50065212 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_138281 (CHEMBL744238) |
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IC50 | 1620±n/a nM |
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Citation | Tecle, H; Barrett, SD; Lauffer, DJ; Augelli-Szafran, C; Brann, MR; Callahan, MJ; Caprathe, BW; Davis, RE; Doyle, PD; Eubanks, D; Lipiniski, W; Mirzadegan, T; Moos, WH; Moreland, DW; Nelson, CB; Pavia, MR; Raby, C; Schwarz, RD; Spencer, CJ; Thomas, AJ; Jaen, JC Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist. J Med Chem41:2524-36 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M1 |
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Name: | Muscarinic acetylcholine receptor M1 |
Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
Type: | Protein |
Mol. Mass.: | 51442.54 |
Organism: | Homo sapiens (Human) |
Description: | P11229 |
Residue: | 460 |
Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50065212 |
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n/a |
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Name | BDBM50065212 |
Synonyms: | 1-Aza-bicyclo[2.2.1]heptan-3-one O-(3-thiophen-2-yl-prop-2-ynyl)-oxime | CHEMBL85936 |
Type | Small organic molecule |
Emp. Form. | C13H14N2OS |
Mol. Mass. | 246.328 |
SMILES | C(O\N=C1/CN2CCC1C2)C#Cc1cccs1 |
Structure |
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