Reaction Details |
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Target | Muscarinic acetylcholine receptor M2 |
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Ligand | BDBM50065224 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_139625 (CHEMBL749007) |
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IC50 | 519.0±n/a nM |
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Citation | Tecle, H; Barrett, SD; Lauffer, DJ; Augelli-Szafran, C; Brann, MR; Callahan, MJ; Caprathe, BW; Davis, RE; Doyle, PD; Eubanks, D; Lipiniski, W; Mirzadegan, T; Moos, WH; Moreland, DW; Nelson, CB; Pavia, MR; Raby, C; Schwarz, RD; Spencer, CJ; Thomas, AJ; Jaen, JC Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist. J Med Chem41:2524-36 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M2 |
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Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
Type: | GPCR |
Mol. Mass.: | 51730.61 |
Organism: | Homo sapiens (Human) |
Description: | P08172 |
Residue: | 466 |
Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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BDBM50065224 |
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n/a |
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Name | BDBM50065224 |
Synonyms: | 1-Aza-bicyclo[2.2.1]heptan-3-one O-(3-methyl-but-2-enyl)-oxime | CHEMBL82378 |
Type | Small organic molecule |
Emp. Form. | C11H18N2O |
Mol. Mass. | 194.2734 |
SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#8]\[#7]=[#6]-1/[#6]-[#7]-2-[#6]-[#6]-[#6]-1-[#6]-2 |
Structure |
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