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Target5-hydroxytryptamine receptor 1A
LigandBDBM50065565
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1127 (CHEMBL616072)
Ki 9.53±n/a nM
Citation Yasunaga, TKimura, TNaito, RKontani, TWanibuchi, FYamashita, HNomura, TTsukamoto, SYamaguchi, TMase, T Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists. J Med Chem41:2765-78 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 1A
Name:5-hydroxytryptamine receptor 1A
Synonyms:5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46445.29
Organism:Rattus norvegicus (rat)
Description:Binding assays were performed using rat hippocampal membranes.
Residue:422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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  Blast E-value cutoff:
BDBM50065565
n/a
NameBDBM50065565
Synonyms:CHEMBL92651 | [2-(6-Fluoro-2-methyl-chroman-8-yloxy)-ethyl]-[3-(4-methoxy-phenyl)-propyl]-amine
TypeSmall organic molecule
Emp. Form.C22H28FNO3
Mol. Mass.373.461
SMILESCOc1ccc(CCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: