Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50065582 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1127 (CHEMBL616072) |
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Ki | 2.34±n/a nM |
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Citation | Yasunaga, T; Kimura, T; Naito, R; Kontani, T; Wanibuchi, F; Yamashita, H; Nomura, T; Tsukamoto, S; Yamaguchi, T; Mase, T Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists. J Med Chem41:2765-78 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50065582 |
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n/a |
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Name | BDBM50065582 |
Synonyms: | 6-Fluoro-8-{2-[2-(4-methoxy-phenyl)-ethylamino]-ethoxy}-chroman-4-ol | CHEMBL96517 |
Type | Small organic molecule |
Emp. Form. | C20H24FNO4 |
Mol. Mass. | 361.4073 |
SMILES | COc1ccc(CCNCCOc2cc(F)cc3C(O)CCOc23)cc1 |
Structure |
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