| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein |
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| Ligand | BDBM50065593 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_160898 (CHEMBL771794) |
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| Ki | 146±n/a nM |
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| Citation |  Webber, SE; Okano, K; Little, TL; Reich, SH; Xin, Y; Fuhrman, SA; Matthews, DA; Love, RA; Hendrickson, TF; Patick, AK; Meador, JW; Ferre, RA; Brown, EL; Ford, CE; Binford, SL; Worland, ST Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements. J Med Chem41:2786-805 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein |
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| Name: | Genome polyprotein |
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| Synonyms: | Human rhinovirus A protease | Human rhinovirus B 3A protease |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44361.04 |
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| Organism: | Human rhinovirus B |
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| Description: | ChEMBL_158953 |
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| Residue: | 401 |
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| Sequence: | AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMS
AIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIA
NIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVIT
TGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDR
NEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYN
YPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQT
IHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
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| BDBM50065593 |
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| n/a |
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| Name | BDBM50065593 |
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| Synonyms: | ((S)-1-{(S)-1-[(S)-1-Formyl-2-(2,2,2-trifluoro-acetylamino)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester | CHEMBL94600 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33F3N4O6 |
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| Mol. Mass. | 578.58 |
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| SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CNC(=O)C(F)(F)F)C=O |
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| Structure | 
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