Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50066381 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63360 (CHEMBL679124) |
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IC50 | 0.64±n/a nM |
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Citation | Liu, G; Henry, KJ; Szczepankiewicz, BG; Winn, M; Kozmina, NS; Boyd, SA; Wasicak, J; von Geldern, TW; Wu-Wong, JR; Chiou, WJ; Dixon, DB; Nguyen, B; Marsh, KC; Opgenorth, TJ Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). J Med Chem41:3261-75 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48256.91 |
Organism: | RAT |
Description: | ENDOTHELIN A EDNRA RAT::P26684 |
Residue: | 426 |
Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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BDBM50066381 |
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n/a |
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Name | BDBM50066381 |
Synonyms: | (2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-cyclopropylidene-propyl)-1-dibutylcarbamoylmethyl-pyrrolidine-3-carboxylic acid | CHEMBL323485 |
Type | Small organic molecule |
Emp. Form. | C28H40N2O5 |
Mol. Mass. | 484.6276 |
SMILES | [#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6])-[#6](=O)-[#6]-[#7]-1-[#6]-[#6@@H](-[#6@H](-[#6@@H]-1-[#6]-[#6]\[#6]=[#6]-1/[#6]-[#6]-1)-[#6](-[#8])=O)-c1ccc2-[#8]-[#6]-[#8]-c2c1 |
Structure |
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