Reaction Details |
| Report a problem with these data |
Target | Procathepsin L |
---|
Ligand | BDBM19810 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_48507 (CHEMBL660656) |
---|
Ki | 16±n/a nM |
---|
Citation | Marquis, RW; Yamashita, DS; Ru, Y; LoCastro, SM; Oh, HJ; Erhard, KF; DesJarlais, RL; Head, MS; Smith, WW; Zhao, B; Janson, CA; Abdel-Meguid, SS; Tomaszek, TA; Levy, MA; Veber, DF Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K. J Med Chem41:3563-7 (1998) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Procathepsin L |
---|
Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
|
|
|
BDBM19810 |
---|
n/a |
---|
Name | BDBM19810 |
Synonyms: | CHEMBL118449 | benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl]-3-oxopiperidin-4-yl}carbamoyl)-3-methylbutyl]carbamate | piperidinone analogue, 27 |
Type | Small organic molecule |
Emp. Form. | C33H44N4O7 |
Mol. Mass. | 608.7251 |
SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCN(CC1=O)C(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| |
Structure |
|