| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50066645 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_47585 (CHEMBL657188) |
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| Ki | >1000±n/a nM |
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| Citation |  Marquis, RW; Yamashita, DS; Ru, Y; LoCastro, SM; Oh, HJ; Erhard, KF; DesJarlais, RL; Head, MS; Smith, WW; Zhao, B; Janson, CA; Abdel-Meguid, SS; Tomaszek, TA; Levy, MA; Veber, DF Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K. J Med Chem41:3563-7 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50066645 |
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| n/a |
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| Name | BDBM50066645 |
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| Synonyms: | CHEMBL432634 | {(S)-3-Methyl-1-[1-(4-methyl-pentyl)-3-oxo-piperidin-4-ylcarbamoyl]-butyl}-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C25H39N3O4 |
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| Mol. Mass. | 445.5949 |
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| SMILES | CC(C)CCCN1CCC(NC(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)C(=O)C1 |
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| Structure | 
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