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TargetReverse transcriptase/RNaseH
LigandBDBM50066927
Substrate/Competitorn/a
Meas. Tech.ChEMBL_195847 (CHEMBL799146)
IC50 460±n/a nM
Citation Nugent, RASchlachter, STMurphy, MJCleek, GJPoel, TJWishka, DGGraber, DRYagi, YKeiser, BJOlmsted, RAKopta, LASwaney, SMPoppe, SMMorris, JTarpley, WGThomas, RC Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV. J Med Chem41:3793-803 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Reverse transcriptase/RNaseH
Name:Reverse transcriptase/RNaseH
Synonyms:HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50066927
n/a
NameBDBM50066927
Synonyms:6-Chloro-2-(naphthalen-2-ylmethylsulfanyl)-pyrimidin-4-ylamine | CHEMBL124494
TypeSmall organic molecule
Emp. Form.C15H12ClN3S
Mol. Mass.301.794
SMILESNc1cc(Cl)nc(SCc2ccc3ccccc3c2)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: