| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50066925 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195847 (CHEMBL799146) |
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| IC50 | 980±n/a nM |
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| Citation |  Nugent, RA; Schlachter, ST; Murphy, MJ; Cleek, GJ; Poel, TJ; Wishka, DG; Graber, DR; Yagi, Y; Keiser, BJ; Olmsted, RA; Kopta, LA; Swaney, SM; Poppe, SM; Morris, J; Tarpley, WG; Thomas, RC Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV. J Med Chem41:3793-803 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50066925 |
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| n/a |
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| Name | BDBM50066925 |
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| Synonyms: | 6-Chloro-2-(3-methoxy-benzylsulfanyl)-pyrimidin-4-ylamine | CHEMBL334129 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12ClN3OS |
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| Mol. Mass. | 281.761 |
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| SMILES | COc1cccc(CSc2nc(N)cc(Cl)n2)c1 |
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| Structure | 
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