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TargetAldo-keto reductase family 1 member B1
LigandBDBM50067379
Substrate/Competitorn/a
Meas. Tech.ChEMBL_31797 (CHEMBL643203)
IC50 35±n/a nM
Citation Negoro, TMurata, MUeda, SFujitani, BOno, YKuromiya, AKomiya, MSuzuki, KMatsumoto, J Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. J Med Chem41:4118-29 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family 1 member B1
Name:Aldo-keto reductase family 1 member B1
Synonyms:AKR1B1 | ALDR_PIG | ALR2 | AR | Aldose reductase
Type:PROTEIN
Mol. Mass.:35865.31
Organism:Sus scrofa
Description:ChEMBL_502637
Residue:316
Sequence:
MASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQ
EKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGK
DPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKP
AVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
YNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCA
LMSCASHKDYPFHEEY
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  Blast E-value cutoff:
BDBM50067379
n/a
NameBDBM50067379
Synonyms:2'-(3-chlorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3',4'-tetrahydropyrrolo[1,2-a]pyrazine)]-1',2,3',5-tetraone | CHEMBL133475
TypeSmall organic molecule
Emp. Form.C17H12ClN3O4
Mol. Mass.357.748
SMILESClc1cccc(CN2C(=O)c3cccn3C3(CC(=O)NC3=O)C2=O)c1
Structure
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