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TargetAldo-keto reductase family 1 member B1
LigandBDBM50067400
Substrate/Competitorn/a
Meas. Tech.ChEMBL_31797 (CHEMBL643203)
IC50 40±n/a nM
Citation Negoro, TMurata, MUeda, SFujitani, BOno, YKuromiya, AKomiya, MSuzuki, KMatsumoto, J Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. J Med Chem41:4118-29 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family 1 member B1
Name:Aldo-keto reductase family 1 member B1
Synonyms:AKR1B1 | ALDR_PIG | ALR2 | AR | Aldose reductase
Type:PROTEIN
Mol. Mass.:35865.31
Organism:Sus scrofa
Description:ChEMBL_502637
Residue:316
Sequence:
MASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQ
EKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGK
DPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKP
AVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
YNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCA
LMSCASHKDYPFHEEY
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  Blast E-value cutoff:
BDBM50067400
n/a
NameBDBM50067400
Synonyms:6'-bromo-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3',4'-tetrahydropyrrolo[1,2-a]pyrazine)]-1',2,3',5-tetraone | CHEMBL335972
TypeSmall organic molecule
Emp. Form.C17H10Br2FN3O4
Mol. Mass.499.085
SMILESFc1cc(Br)ccc1CN1C(=O)c2ccc(Br)n2C2(CC(=O)NC2=O)C1=O
Structure
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