Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM50067400 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_31797 (CHEMBL643203) |
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IC50 | 40±n/a nM |
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Citation | Negoro, T; Murata, M; Ueda, S; Fujitani, B; Ono, Y; Kuromiya, A; Komiya, M; Suzuki, K; Matsumoto, J Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. J Med Chem41:4118-29 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR_PIG | ALR2 | AR | Aldose reductase |
Type: | PROTEIN |
Mol. Mass.: | 35865.31 |
Organism: | Sus scrofa |
Description: | ChEMBL_502637 |
Residue: | 316 |
Sequence: | MASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQ
EKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGK
DPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKP
AVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
YNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCA
LMSCASHKDYPFHEEY
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BDBM50067400 |
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n/a |
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Name | BDBM50067400 |
Synonyms: | 6'-bromo-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3',4'-tetrahydropyrrolo[1,2-a]pyrazine)]-1',2,3',5-tetraone | CHEMBL335972 |
Type | Small organic molecule |
Emp. Form. | C17H10Br2FN3O4 |
Mol. Mass. | 499.085 |
SMILES | Fc1cc(Br)ccc1CN1C(=O)c2ccc(Br)n2C2(CC(=O)NC2=O)C1=O |
Structure |
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