Reaction Details |
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Target | Chymase |
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Ligand | BDBM50068901 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_49442 |
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Ki | 1.3±n/a nM |
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Citation | Eda, M; Ashimori, A; Akahoshi, F; Yoshimura, T; Inoue, Y; Fukaya, C; Nakajima, M; Fukuyama, H; Imada, T; Takai, S; Shiota, N; Miyazaki, M; Nakamura, N Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites. Bioorg Med Chem Lett8:913-8 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Chymase |
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Name: | Chymase |
Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
Type: | Enzyme |
Mol. Mass.: | 27340.12 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 247 |
Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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BDBM50068901 |
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n/a |
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Name | BDBM50068901 |
Synonyms: | 3-[2,2-Difluoro-4-({(S)-1-[(S)-3-methyl-2-(3-phenyl-propionylamino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-oxo-5-phenyl-pentanoylamino]-benzoic acid | CHEMBL353816 |
Type | Small organic molecule |
Emp. Form. | C37H40F2N4O7 |
Mol. Mass. | 690.7329 |
SMILES | CC(C)[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O |
Structure |
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