Reaction Details |
| Report a problem with these data |
Target | Caspase-1 |
---|
Ligand | BDBM50068951 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_90979 |
---|
Ki | 2.4±n/a nM |
---|
Citation | Semple, G; Ashworth, DM; Batt, AR; Baxter, AJ; Benzies, DW; Elliot, LH; Evans, DM; Franklin, RJ; Hudson, P; Jenkins, PD; Pitt, GR; Rooker, DP; Yamamoto, S; Isomura, Y Peptidomimetic aminomethylene ketone inhibitors of interleukin-1 beta-converting enzyme (ICE). Bioorg Med Chem Lett8:959-64 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Caspase-1 |
---|
Name: | Caspase-1 |
Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
Type: | Enzyme |
Mol. Mass.: | 45154.13 |
Organism: | Homo sapiens (Human) |
Description: | P29466 |
Residue: | 404 |
Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
|
|
BDBM50068951 |
---|
n/a |
---|
Name | BDBM50068951 |
Synonyms: | (S)-5-Dihexylamino-3-(2-{3-[(naphthalene-2-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-butyrylamino)-4-oxo-pentanoic acid | CHEMBL368078 |
Type | Small organic molecule |
Emp. Form. | C37H50N4O6 |
Mol. Mass. | 646.8161 |
SMILES | CCCCCCN(CCCCCC)CC(=O)[C@H](CC(O)=O)NC(=O)C(CC)n1cccc(NC(=O)c2ccc3ccccc3c2)c1=O |
Structure |
|