Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50069029 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_80095 |
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Ki | 0.041000±n/a nM |
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Citation | Rodgers, JD; Johnson, BL; Wang, H; Erickson-Viitanen, S; Klabe, RM; Bacheler, L; Cordova, BC; Chang, CH Potent cyclic urea HIV protease inhibitors with 3-aminoindazole P2/P2' groups. Bioorg Med Chem Lett8:715-20 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50069029 |
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n/a |
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Name | BDBM50069029 |
Synonyms: | (4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-(3-ethylamino-1H-indazol-5-ylmethyl)-5,6-dihydroxy-[1,3]diazepan-2-one | CHEMBL351172 |
Type | Small organic molecule |
Emp. Form. | C39H44N8O3 |
Mol. Mass. | 672.8185 |
SMILES | CCNc1[nH]nc2ccc(CN3[C@H](Cc4ccccc4)[C@H](O)[C@@H](O)[C@@H](Cc4ccccc4)N(Cc4ccc5n[nH]c(NCC)c5c4)C3=O)cc12 |
Structure |
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