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TargetTrypsin-1
LigandBDBM50069163
Substrate/Competitorn/a
Meas. Tech.ChEMBL_210652
Ki 7.1±n/a nM
Citation Duncia JVSantella JBHigley CAVanAtten MKWeber PCAlexander RSKettner CAPruitt JRLiauw AYQuan MLKnabb RMWexler RR Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors. Bioorg Med Chem Lett 8:775-80 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Trypsin-1
Name:Trypsin-1
Synonyms:Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | Trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:26557.80
Organism:Homo sapiens (Human)
Description:P07477
Residue:247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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  Blast E-value cutoff:
BDBM50069163
n/a
NameBDBM50069163
Synonyms:3-(1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-yl)-propionic acid | CHEMBL2373400
TypeSmall organic molecule
Emp. Form.C29H42BN5O5
Mol. Mass.551.485
SMILES[H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(O[C@]1([H])C2)[C@H](CCCCN)NC(=O)Cn1nc(CCC(O)=O)nc1Cc1ccccc1
Structure
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