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TargetStromelysin-1
LigandBDBM50069220
Substrate/Competitorn/a
Meas. Tech.ChEBML_101949
Ki 25±n/a nM
Citation Jacobson, ICReddy, PGWasserman, ZRHardman, KDCovington, MBArner, ECCopeland, RADecicco, CPMagolda, RL Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett8:837-42 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Stromelysin-1
Name:Stromelysin-1
Synonyms:MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:Enzyme
Mol. Mass.:53973.13
Organism:Homo sapiens (Human)
Description: P08254
Residue:477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50069220
n/a
NameBDBM50069220
Synonyms:(2R,3R)-2,N*1*-Dihydroxy-N*4*-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-2-methyl-3-phenethyl-succinamide | CHEMBL167278
TypeSmall organic molecule
Emp. Form.C24H31N3O6
Mol. Mass.457.5194
SMILESCNC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](CCc1ccccc1)[C@@](C)(O)C(=O)NO
Structure
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