Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50069948 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_52889 |
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Ki | 25±n/a nM |
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Citation | Pitts, WJ; Jetter, JW; Pinto, DJ; Orwat, MJ; Batt, DG; Sherk, SR; Petraitis, JJ; Jacobson, IC; Copeland, RA; Dowling, RL; Jaffee, BD; Gardner, TL; Jones, EA; Magolda, RL Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium. Bioorg Med Chem Lett8:307-12 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM50069948 |
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n/a |
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Name | BDBM50069948 |
Synonyms: | CHEMBL107209 | Sodium; 9-fluoro-3-(3-methoxy-phenyl)-5,6-dihydro-benzo[c]acridine-7-carboxylate |
Type | Small organic molecule |
Emp. Form. | C25H17FNO3 |
Mol. Mass. | 398.4063 |
SMILES | COc1cccc(c1)-c1ccc-2c(CCc3c-2nc2ccc(F)cc2c3C([O-])=O)c1 |
Structure |
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