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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM50069964
Substrate/Competitorn/a
Meas. Tech.ChEBML_52889
Ki 206±n/a nM
Citation Pitts, WJJetter, JWPinto, DJOrwat, MJBatt, DGSherk, SRPetraitis, JJJacobson, ICCopeland, RADowling, RLJaffee, BDGardner, TLJones, EAMagolda, RL Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium. Bioorg Med Chem Lett8:307-12 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50069964
n/a
NameBDBM50069964
Synonyms:CHEMBL324668 | Sodium; 9-fluoro-5-oxo-3-phenyl-5,6-dihydro-5lambda*4*-thiochromeno[4,3-b]quinoline-7-carboxylate
TypeSmall organic molecule
Emp. Form.C23H13FNO3S
Mol. Mass.402.418
SMILES[O-]C(=O)c1c2CS(=O)c3cc(ccc3-c2nc2ccc(F)cc12)-c1ccccc1
Structure
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