| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50070244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_105964 |
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| IC50 | >20±n/a nM |
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| Citation |  Campbell, DA; Xiao, XY; Harris, D; Ida, S; Mortezaei, R; Ngu, K; Shi, L; Tien, D; Wang, Y; Navre, M; Patel, DV; Sharr, MA; DiJoseph, JF; Killar, LM; Leone, CL; Levin, JI; Skotnicki, JS Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors. Bioorg Med Chem Lett8:1157-62 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50070244 |
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| n/a |
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| Name | BDBM50070244 |
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| Synonyms: | 2-(1-Hydroxy-2-mercapto-ethyl)-nonanoic acid [(S)-2-cyclohexyl-1-(2-morpholin-4-yl-ethylcarbamoyl)-ethyl]-amide | CHEMBL16154 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H49N3O4S |
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| Mol. Mass. | 499.75 |
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| SMILES | CCCCCCCC(C(O)CS)C(=O)N[C@@H](CC1CCCCC1)C(=O)NCCN1CCOCC1 |
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| Structure | 
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