| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Matrix metalloproteinase-9 |
|---|
| Ligand | BDBM50063920 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_105236 |
|---|
| IC50 | 12±n/a nM |
|---|
| Citation |  Levin, JI; DiJoseph, JF; Killar, LM; Sharr, MA; Skotnicki, JS; Patel, DV; Xiao, XY; Shi, L; Navre, M; Campbell, DA The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett8:1163-8 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Matrix metalloproteinase-9 |
|---|
| Name: | Matrix metalloproteinase-9 |
|---|
| Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 78452.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14780 |
|---|
| Residue: | 707 |
|---|
| Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
|
|
|
|---|
| BDBM50063920 |
|---|
| n/a |
|---|
| Name | BDBM50063920 |
|---|
| Synonyms: | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-isobutyl-succinamide | (R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide | CHEMBL16520 | Ro-31-9790 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H29N3O4 |
|---|
| Mol. Mass. | 315.4085 |
|---|
| SMILES | CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)CC(=O)NO)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
