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TargetHuman immunodeficiency virus type 1 reverse transcriptase
LigandBDBM50070539
Substrate/Competitorn/a
Meas. Tech.ChEMBL_196517
IC50 12000±n/a nM
Citation Sahlberg CNoréen REngelhardt PHögberg MKangasmetsä JVrang LZhang H Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg Med Chem Lett 8:1511-6 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 reverse transcriptase
Name:Human immunodeficiency virus type 1 reverse transcriptase
Synonyms:Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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  Blast E-value cutoff:
BDBM50070539
n/a
NameBDBM50070539
Synonyms:(S)-9-Chloro-8-methyl-7-(3-methyl-but-2-enyl)-6,7,8,9-tetrahydro-2H-2,7,9a-triaza-benzo[cd]azulene-1-thione | CHEMBL35434
TypeSmall organic molecule
Emp. Form.C16H20ClN3S
Mol. Mass.321.868
SMILESC[C@H]1C(Cl)n2c3c(CN1CC=C(C)C)cccc3[nH]c2=S |wD:1.0,(15.35,-13.04,;14.11,-13.39,;13.57,-11.93,;14.63,-10.79,;12.02,-11.48,;10.69,-12.43,;10.69,-14,;11.82,-14.79,;13.37,-14.48,;14.08,-15.54,;15.35,-15.46,;16.05,-16.52,;15.48,-17.66,;17.32,-16.44,;9.36,-14.77,;8.01,-14.01,;8.01,-12.44,;9.36,-11.66,;9.34,-10.13,;11.74,-9.87,;12.51,-8.86,)|
Structure
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