| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50070856 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_52890 |
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| Ki | 30±n/a nM |
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| Citation |  Batt, DG; Petraitis, JJ; Sherk, SR; Copeland, RA; Dowling, RL; Taylor, TL; Jones, EA; Magolda, RL; Jaffee, BD Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents. Bioorg Med Chem Lett8:1745-50 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM50070856 |
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| n/a |
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| Name | BDBM50070856 |
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| Synonyms: | CHEMBL51243 | Sodium; 6-fluoro-2-(6-fluoro-4-phenyl-2,3-dihydro-indol-1-yl)-3-methyl-quinoline-4-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C25H17F2N2O2 |
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| Mol. Mass. | 415.412 |
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| SMILES | Cc1c(nc2ccc(F)cc2c1C([O-])=O)N1CCc2c1cc(F)cc2-c1ccccc1 |
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| Structure | 
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