| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50071442 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_65820 |
|---|
| Ki | 8.6±n/a nM |
|---|
| Citation |  Sakaki, J; Murata, T; Yuumoto, Y; Nakamura, I; Trueh, T; Pitterna, T; Iwasaki, G; Oda, K; Yamamura, T; Hayakawa, K Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity. Bioorg Med Chem Lett8:2241-6 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48736.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25101 |
|---|
| Residue: | 427 |
|---|
| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
|
|
|
|---|
| BDBM50071442 |
|---|
| n/a |
|---|
| Name | BDBM50071442 |
|---|
| Synonyms: | CHEMBL72358 | N-[(R)-1-[2-(Butane-1-sulfonylamino)-1-cyclohexyl-2-oxo-ethylcarbamoyl]-2-(4-isoxazol-5-yl-phenyl)-ethyl]-3,5,N-trimethyl-benzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H44N4O6S |
|---|
| Mol. Mass. | 636.801 |
|---|
| SMILES | CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(cc1)-c1ccno1)N(C)C(=O)c1cc(C)cc(C)c1)C1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
