| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50071764 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_197451 (CHEMBL804236) |
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| IC50 | 15000±n/a nM |
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| Citation |  Milton, J; Slater, MJ; Bird, AJ; Spinks, D; Scott, G; Price, CE; Downing, S; Green, DV; Madar, S; Bethell, R; Stammers, DK Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2. Bioorg Med Chem Lett8:2623-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50071764 |
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| n/a |
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| Name | BDBM50071764 |
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| Synonyms: | 5-Bromo-2-[5-(4-bromo-phenylcarbamoyl)-pentanoylamino]-benzoic acid | CHEMBL314121 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18Br2N2O4 |
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| Mol. Mass. | 498.165 |
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| SMILES | OC(=O)c1cc(Br)ccc1NC(=O)CCCCC(=O)Nc1ccc(Br)cc1 |
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| Structure | 
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