| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50071779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196364 (CHEMBL805997) |
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| IC50 | 6900±n/a nM |
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| Citation |  Milton, J; Slater, MJ; Bird, AJ; Spinks, D; Scott, G; Price, CE; Downing, S; Green, DV; Madar, S; Bethell, R; Stammers, DK Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2. Bioorg Med Chem Lett8:2623-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50071779 |
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| n/a |
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| Name | BDBM50071779 |
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| Synonyms: | 2-[4-(2-carboxy-4-methylsulfanylphenylcarbamoyl)butylcarboxamido]-5-methylsulfanylbenzoic acid | CHEMBL90333 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N2O6S2 |
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| Mol. Mass. | 476.566 |
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| SMILES | CSc1ccc(NC(=O)CCCCC(=O)Nc2ccc(SC)cc2C(O)=O)c(c1)C(O)=O |
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| Structure | 
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