| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 11 |
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| Ligand | BDBM50071867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_124652 |
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| IC50 | 10±n/a nM |
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| Citation |  de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett8:2689-94 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 11 |
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| Name: | Mitogen-activated protein kinase 11 |
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| Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41351.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_20128774 |
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| Residue: | 364 |
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| Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
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| BDBM50071867 |
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| n/a |
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| Name | BDBM50071867 |
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| Synonyms: | 4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrrol-3-yl]-pyridine | CHEMBL316275 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17FN2O2S |
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| Mol. Mass. | 392.446 |
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| SMILES | CS(=O)(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 |
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| Structure | 
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