| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-1 |
|---|
| Ligand | BDBM50072040 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_46514 |
|---|
| IC50 | 523±n/a nM |
|---|
| Citation |  Karanewsky, DS; Bai, X; Linton, SD; Krebs, JF; Wu, J; Pham, B; Tomaselli, KJ Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain). Bioorg Med Chem Lett8:2757-62 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-1 |
|---|
| Name: | Caspase-1 |
|---|
| Synonyms: | CASP1_MOUSE | Casp1 | Il1bc |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 45636.44 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_651546 |
|---|
| Residue: | 402 |
|---|
| Sequence: | MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDH
VSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNK
EDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVG
AQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQE
GICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRD
SEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAW
SCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
|
|
|
|---|
| BDBM50072040 |
|---|
| n/a |
|---|
| Name | BDBM50072040 |
|---|
| Synonyms: | 3-Acetylamino-N-{(S)-1-[(S)-1-((S)-2-hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethylcarbamoyl]-2-methyl-propyl}-succinamic acid | CHEMBL2370213 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H28N4O9 |
|---|
| Mol. Mass. | 444.4363 |
|---|
| SMILES | CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@H]1CC(=O)OC1O |
|---|
| Structure | 
|
|---|
Search and Browse
