| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Ligand | BDBM50072211 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_155172 |
|---|
| IC50 | 80±n/a nM |
|---|
| Citation |  Charpiot, B; Brun, J; Donze, I; Naef, R; Stefani, M; Mueller, T Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors. Bioorg Med Chem Lett8:2891-6 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Synonyms: | DPDE4 | PDE4B_RAT | Pde4b | Phosphodiesterase 4B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 83349.50 |
|---|
| Organism: | RAT |
|---|
| Description: | P14646 |
|---|
| Residue: | 736 |
|---|
| Sequence: | MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSSGLVL
HAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRIVR
NNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLE
ETDIDIATEDKSLIDT
|
|
|
|---|
| BDBM50072211 |
|---|
| n/a |
|---|
| Name | BDBM50072211 |
|---|
| Synonyms: | 2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydroxy-ethoxy)-6-methoxy-quinazolin-2-yloxy]-ethanol | CHEMBL98662 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H32N2O7 |
|---|
| Mol. Mass. | 496.5522 |
|---|
| SMILES | COc1cc2c(nc(OCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
