| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D |
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| Ligand | BDBM50072209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157218 (CHEMBL769542) |
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| IC50 | 200±n/a nM |
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| Citation |  Charpiot, B; Brun, J; Donze, I; Naef, R; Stefani, M; Mueller, T Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors. Bioorg Med Chem Lett8:2891-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D |
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| Synonyms: | Phosphodiesterase 4 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 193660 |
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| Components: | This complex has 4 components. |
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| Component 1 |
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Synonyms: | DPDE4 | PDE4B_RAT | Pde4b | Phosphodiesterase 4B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 83349.50 |
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| Organism: | RAT |
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| Description: | P14646 |
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| Residue: | 736 |
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| Sequence: | MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSSGLVL
HAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRIVR
NNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLE
ETDIDIATEDKSLIDT
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| Component 2 |
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Synonyms: | DPDE3 | PDE4D_RAT | Pde4d |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90531.57 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 803 |
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| Sequence: | MEAEGSSVPARAGSHEGSDSSGGAALKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHRGYSDTERYLYCRAMDRTS
YAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHS
QRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTN
LQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMAS
NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQIS
GVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMH
TIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEA
VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE
ENCDIFQNLTKKQRQSLRKMAIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY
SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA
SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQED
GRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVE
EEAVAEEESQPQTGVADDCCPDT
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| Component 3 |
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
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| Synonyms: | DPDE2 | PDE4A_RAT | Pde4a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93412.58 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 844 |
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| Sequence: | MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYPDSAERSETERS
PHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDS
QASPGLVLHAGATTSQRRESFLYRSDSDYDMSPKAVSRSSSVASEAHAEDLIVTPFAQVL
ASLRSVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQL
ETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNEVEIPSPTP
RQRAFQQPPPSVLRQSQPMSQITGLKKLVHTGSLNTNVPRFGVKTDQEDLLAQELENLSK
WGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMMYMLTLEDHYHADVAYHN
SLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELAL
MYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLA
DLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFF
QQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLED
NRDWYHSAIRQSPSPPLEEEPGGLGHPSLPDKFQFELTLEEEEEEDSLEVPGLPTTEETF
LAAEDARAQAVDWSKVKGPSTTVVEVAERLKQETASAYGAPQESMEAVGCSFSPGTPILP
DVRTLSSSEEAPGLLGLPSTAAEVEAPRDHLAATRACSACSGTSGDNSAIISAPGRWGSG
GDPA
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| Component 4 |
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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| BDBM50072209 |
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| n/a |
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| Name | BDBM50072209 |
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| Synonyms: | 3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydroxy-ethoxy)-6-methoxy-quinazolin-2-ylamino]-propan-1-ol | CHEMBL97785 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35N3O6 |
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| Mol. Mass. | 509.594 |
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| SMILES | COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1 |
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| Structure | 
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