| Reaction Details |
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 | Report a problem with these data |
| Target | Thyrotropin-releasing hormone receptor |
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| Ligand | BDBM50072397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210510 (CHEMBL811905) |
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| Ki | 36000±n/a nM |
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| Citation |  Chu, W; Perlman, JH; Gershengorn, MC; Moeller, KD Thyrotropin releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics. Bioorg Med Chem Lett8:3093-6 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyrotropin-releasing hormone receptor |
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| Name: | Thyrotropin-releasing hormone receptor |
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| Synonyms: | TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44568.52 |
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| Organism: | MOUSE |
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| Description: | thyrotropin-releasing hormone R1 TRHR MOUSE::P21761 |
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| Residue: | 393 |
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| Sequence: | MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIH
QNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKES
DRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
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| BDBM50072397 |
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| n/a |
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| Name | BDBM50072397 |
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| Synonyms: | 7-cyclohexyl-6-(2,6-dioxo-1,7-diazaspiro[4.4]non-7-yl)-5-oxo-(8aS)-1,2,3,5,8,8a-hexahydro-3-indolizinecarboxamide | CHEMBL319910 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N4O4 |
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| Mol. Mass. | 414.498 |
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| SMILES | NC(=O)[C@@H]1CC[C@@H]2CC(C3CCCCC3)=C(N3CC[C@]4(CCC(=O)N4)C3=O)C(=O)N12 |t:15| |
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| Structure | 
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