Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50073754 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54286 |
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Ki | 0.290000±n/a nM |
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Citation | Gossett, LS; Habeck, LL; Shackelford, KA; Mendelsohn, LG; Gates, SB; Worzalla, JF; Self, TD; Theobald, KS; Andis, SL; Schultz, RM; Shih, C The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents. Bioorg Med Chem Lett9:75-8 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50073754 |
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n/a |
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Name | BDBM50073754 |
Synonyms: | (R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-2-methyl-pentanedioic acid | CHEMBL354249 | LY-335518 |
Type | Small organic molecule |
Emp. Form. | C22H28N6O5 |
Mol. Mass. | 456.4949 |
SMILES | C[C@](CCC(O)=O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)cc1)C(O)=O |
Structure |
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