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TargetCalpain 1/2
LigandBDBM50073850
Substrate/Competitorn/a
Meas. Tech.ChEBML_43477
Ki 10±n/a nM
Citation Angelastro MRMarquart ALMehdi SKoehl JRVaz RJBey PPeet NP The synthesis of ketomethylene pseudopeptide analogues of dipeptide aldehyde inhibitors of calpain. Bioorg Med Chem Lett 9:139-40 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Calpain 1/2
Name:Calpain 1/2
Synonyms:CANP | Calcium-activated neutral proteinase | Calpain-1 catalytic subunit | Calpain-1 large subunit | Mu/M-type
Type:PROTEIN
Mol. Mass.:80319.95
Organism:Gallus gallus
Description:ChEMBL_43477
Residue:705
Sequence:
MMPFGGIAARLQRDRLRAEGVGEHNNAVKYLNQDYEALKQECIESGTLFRDPQFPAGPTA
LGFKELGPYSSKTRGVEWKRPSELVDDPQFIVGGATRTDICQGALGDCWLLAAIGSLTLN
EELLHRVVPHGQSFQEDYAGIFHFQIWQFGEWVDVVVDDLLPTKDGELLFVHSAECTEFW
SALLEKAYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLKRAPRNMGHIIRKALERGSL
LGCSIDITSAFDMEAVTFKKLVKGHAYSVTAFKDVNYRGQQEQLIRIRNPWGQVEWTGAW
SDGSSEWDNIDPSDREELQLKMEDGEFWMSFRDFMREFSRLEICNLTPDALTKDELSRWH
TQVFEGTWRRGSTAGGCRNNPATFWINPQFKIKLLEEDDDPGDDEVACSFLVALMQKHRR
RERRVGGDMHTIGFAVYEVPEEAQGSQNVHLKKDFFLRNQSRARSETFINLREVSNQIRL
PPGEYIVVPSTFEPHKEADFILRVFTEKQSDTAELDEEISADLADEEEITEDDIEDGFKN
MFQQLAGEDMEISVFELKTILNRVIARHKDLKTDGFSLDSCRNMVNLMDKDGSARLGLVE
FQILWNKIRSWLTIFRQYDLDKSGTMSSYEMRMALESAGFKLNNKLHQVVVARYADAETG
VDFDNFVCCLVKLETMFRFFHSMDRDGTGTAVMNLAEWLLLTMCG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50073850
n/a
NameBDBM50073850
Synonyms:(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid | CHEMBL423112 | MDL-28170 | [(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | benzyl (2S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate | benzyl (S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate
TypeSmall organic molecule
Emp. Form.C22H26N2O4
Mol. Mass.382.4528
SMILESCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: