Reaction Details |
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Target | Adenosine receptor A1 |
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Ligand | BDBM50074231 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_29458 (CHEMBL642187) |
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Ki | 41±n/a nM |
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Citation | Li, AH; Moro, S; Forsyth, N; Melman, N; Ji, XD; Jacobson, KA Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem42:706-21 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Adenosine receptor A1 |
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Name: | Adenosine receptor A1 |
Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
Type: | Protein |
Mol. Mass.: | 36704.13 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 326 |
Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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BDBM50074231 |
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n/a |
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Name | BDBM50074231 |
Synonyms: | 4,6-Diethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester | CHEMBL321845 | ethyl 4,6-diethyl-5-(ethylthiocarbonyl)-2-phenylnicotinate |
Type | Small organic molecule |
Emp. Form. | C21H25NO3S |
Mol. Mass. | 371.493 |
SMILES | CCOC(=O)c1c(CC)c(C(=O)SCC)c(CC)nc1-c1ccccc1 |
Structure |
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