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TargetCorticotropin-releasing factor receptor 1
LigandBDBM50074375
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51111 (CHEMBL666549)
Ki 5±n/a nM
Citation Arvanitis, AGGilligan, PJChorvat, RJCheeseman, RSChristos, TEBakthavatchalam, RBeck, JPCocuzza, AJHobbs, FWWilde, RGArnold, CChidester, DCurry, MHe, LHollis, AKlaczkiewicz, JKrenitsky, PJRescinito, JPScholfield, ECulp, SDe Souza, EBFitzgerald, LGrigoriadis, DTam, SWShen, HL Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines. J Med Chem42:805-18 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50074375
n/a
NameBDBM50074375
Synonyms:CHEMBL354395 | N,N-Bis-cyclopropylmethyl-N'-(4-dimethylamino-2-trifluoromethyl-phenyl)-N'-ethyl-6-methyl-[1,3,5]triazine-2,4-diamine
TypeSmall organic molecule
Emp. Form.C23H31F3N6
Mol. Mass.448.5276
SMILESCCN(c1nc(C)nc(n1)N(CC1CC1)CC1CC1)c1ccc(cc1C(F)(F)F)N(C)C
Structure
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