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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50074465 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51114 (CHEMBL664960) | ||
| Ki | 1.4±n/a nM | ||
| Citation |  Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem42:833-48 (1999) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50074465 | |||
| n/a | |||
| Name | BDBM50074465 | ||
| Synonyms: | CHEMBL354982 | [9-(2-Bromo-4-isopropyl-phenyl)-2-methyl-8-trifluoromethyl-9H-purin-6-yl]-butyl-ethyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27BrF3N5 | ||
| Mol. Mass. | 498.382 | ||
| SMILES | CCCCN(CC)c1nc(C)nc2n(c(nc12)C(F)(F)F)-c1ccc(cc1Br)C(C)C |(12.23,1.79,;12.23,.23,;10.9,-.54,;10.9,-2.08,;9.57,-2.85,;8.22,-2.08,;6.89,-2.85,;9.57,-4.39,;8.22,-5.16,;8.22,-6.7,;6.88,-7.47,;9.57,-7.47,;10.9,-6.7,;12.35,-7.17,;13.26,-5.93,;12.35,-4.69,;10.9,-5.16,;14.8,-5.95,;16.34,-5.96,;14.79,-7.47,;14.8,-4.41,;12.68,-8.68,;11.55,-9.71,;11.88,-11.21,;13.33,-11.69,;14.47,-10.65,;14.15,-9.15,;15.41,-8.29,;13.66,-13.21,;12.51,-14.24,;15.13,-13.7,)| | ||
| Structure | 
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