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TargetCorticotropin releasing factor receptor 1
LigandBDBM50074470
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51114
Ki 1.9±n/a nM
Citation Chorvat RJBakthavatchalam RBeck JPGilligan PJWilde RGCocuzza AJHobbs FWCheeseman RSCurry MRescinito JPKrenitsky PChidester DYarem JAKlaczkiewicz JDHodge CNAldrich PEWasserman ZRFernandez CHZaczek RFitzgerald LWHuang SMShen HLWong YNChien BMArvanitis A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem 42:833-48 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Corticotropin releasing factor receptor 1
Name:Corticotropin releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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  Blast E-value cutoff:
BDBM50074470
n/a
NameBDBM50074470
Synonyms:3-(2-Bromo-4-isopropyl-phenyl)-7-(1-ethyl-propoxy)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine | CHEMBL169248
TypeSmall organic molecule
Emp. Form.C19H24BrN5O
Mol. Mass.418.331
SMILESCCC(CC)Oc1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C
Structure
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