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TargetCorticotropin-releasing factor receptor 1
LigandBDBM50074520
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51114 (CHEMBL664960)
Ki 4.3±n/a nM
Citation Chorvat, RJBakthavatchalam, RBeck, JPGilligan, PJWilde, RGCocuzza, AJHobbs, FWCheeseman, RSCurry, MRescinito, JPKrenitsky, PChidester, DYarem, JAKlaczkiewicz, JDHodge, CNAldrich, PEWasserman, ZRFernandez, CHZaczek, RFitzgerald, LWHuang, SMShen, HLWong, YNChien, BMArvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem42:833-48 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50074520
n/a
NameBDBM50074520
Synonyms:Allyl-[3-(2-bromo-4-isopropyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-(2-methoxy-ethyl)-amine | CHEMBL353732
TypeSmall organic molecule
Emp. Form.C20H25BrN6O
Mol. Mass.445.356
SMILESCOCCN(CC=C)c1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C
Structure
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