Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50074527 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_51114 (CHEMBL664960) | ||
Ki | 9.8±n/a nM | ||
Citation | Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem42:833-48 (1999) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50074527 | |||
n/a | |||
Name | BDBM50074527 | ||
Synonyms: | CHEMBL169641 | [3-(2-Bromo-4-isopropyl-phenyl)-2,5-dimethyl-3H-imidazo[4,5-b]pyridin-7-yl]-bis-(2-methoxy-ethyl)-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C23H31BrN4O2 | ||
Mol. Mass. | 475.422 | ||
SMILES | COCCN(CCOC)c1cc(C)nc2n(c(C)nc12)-c1ccc(cc1Br)C(C)C |(13.97,1.76,;13.97,.21,;12.64,-.56,;12.64,-2.11,;11.31,-2.87,;9.98,-2.11,;8.65,-2.87,;7.3,-2.11,;5.97,-2.87,;11.31,-4.41,;9.98,-5.18,;9.98,-6.72,;8.63,-7.5,;11.31,-7.49,;12.64,-6.72,;14.11,-7.19,;15.01,-5.95,;16.55,-5.97,;14.11,-4.71,;12.64,-5.18,;14.74,-8.6,;13.83,-9.84,;14.46,-11.26,;15.99,-11.42,;16.9,-10.17,;16.27,-8.76,;17.18,-7.51,;16.6,-12.84,;15.69,-14.08,;18.14,-13.01,)| | ||
Structure |