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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50074524 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51114 (CHEMBL664960) | ||
| Ki | 7.1±n/a nM | ||
| Citation |  Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem42:833-48 (1999) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50074524 | |||
| n/a | |||
| Name | BDBM50074524 | ||
| Synonyms: | (1-Methyl-butyl)-[5-methyl-3-(2,4,6-trimethyl-phenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-amine | CHEMBL169280 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H26N6 | ||
| Mol. Mass. | 338.4499 | ||
| SMILES | CCCC(C)Nc1nc(C)nc2n(nnc12)-c1c(C)cc(C)cc1C |(7.49,-6.03,;8.82,-5.26,;8.82,-3.72,;10.15,-2.95,;10.15,-1.4,;11.49,-3.72,;11.49,-5.26,;10.15,-6.03,;10.15,-7.57,;8.8,-8.34,;11.49,-8.34,;12.82,-7.57,;14.28,-8.03,;15.17,-6.79,;14.28,-5.55,;12.82,-6.03,;14.61,-9.54,;16.06,-10.02,;17.2,-8.98,;16.39,-11.51,;15.26,-12.55,;15.59,-14.05,;13.79,-12.07,;13.46,-10.58,;11.99,-10.11,)| | ||
| Structure | 
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