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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50074559
Substrate/Competitorn/a
Meas. Tech.ChEMBL_139910 (CHEMBL746846)
EC50 8820±n/a nM
Citation Nassif-Makki, T; Tränkle, C; Zlotos, D; Bejeuhr, G; Cambareri, A; Pfletschinger, C; Kostenis, E; Mohr, K; Holzgrabe, U Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements. J Med Chem42:849-58 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2
Synonyms:ACM2_PIG | CHRM2 | Cholinergic, muscarinic | GPM2 | LOC100715343 | Muscarinic acetylcholine receptor M2 | Muscarinic receptor 2
Type:Enzyme Catalytic Domain
Mol. Mass.:51688.65
Organism:GUINEA PIG
Description:Cholinergic, muscarinic 0 GUINEA PIG::P06199
Residue:466
Sequence:
MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRI
VKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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  Blast E-value cutoff:
BDBM50074559
n/a
NameBDBM50074559
Synonyms:Bis-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-dimethyl-ammonium; bromide | CHEMBL171215
TypeSmall organic molecule
Emp. Form.C24H26N3O4
Mol. Mass.420.4804
SMILESC[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O
Structure
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