| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50074571 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_139910 (CHEMBL746846) |
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| EC50 | 450±n/a nM |
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| Citation |  Nassif-Makki, T; Tränkle, C; Zlotos, D; Bejeuhr, G; Cambareri, A; Pfletschinger, C; Kostenis, E; Mohr, K; Holzgrabe, U Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements. J Med Chem42:849-58 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_PIG | CHRM2 | Cholinergic, muscarinic | GPM2 | LOC100715343 | Muscarinic acetylcholine receptor M2 | Muscarinic receptor 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51688.65 |
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| Organism: | GUINEA PIG |
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| Description: | Cholinergic, muscarinic 0 GUINEA PIG::P06199 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRI
VKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50074571 |
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| n/a |
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| Name | BDBM50074571 |
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| Synonyms: | Bis-{4-{[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propoxyimino]-methyl}-1-methyl-pyridinium}propane; dibromide | CHEMBL169633 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H42N6O6 |
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| Mol. Mass. | 702.797 |
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| SMILES | O=C1N(CCCO\N=C\c2cc[n+](CCCCCC[n+]3ccc(\C=N\OCCCN4C(=O)c5ccccc5C4=O)cc3)cc2)C(=O)c2ccccc12 |
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| Structure | 
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