Reaction Details |
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Target | Metabotropic glutamate receptor 3 |
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Ligand | BDBM50074750 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_106382 (CHEMBL717237) |
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Ki | 170±n/a nM |
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Citation | Monn, JA; Valli, MJ; Massey, SM; Hansen, MM; Kress, TJ; Wepsiec, JP; Harkness, AR; Grutsch, JL; Wright, RA; Johnson, BG; Andis, SL; Kingston, A; Tomlinson, R; Lewis, R; Griffey, KR; Tizzano, JP; Schoepp, DD Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors J Med Chem42:1027-40 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Metabotropic glutamate receptor 3 |
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Name: | Metabotropic glutamate receptor 3 |
Synonyms: | GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 98889.09 |
Organism: | Homo sapiens (Human) |
Description: | metabotropic glutamate 1c 0 HUMAN::Q14832 |
Residue: | 879 |
Sequence: | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
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BDBM50074750 |
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n/a |
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Name | BDBM50074750 |
Synonyms: | (1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid | 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid | CHEMBL8839 | LY-389795 |
Type | Small organic molecule |
Emp. Form. | C7H9NO4S |
Mol. Mass. | 203.216 |
SMILES | N[C@]1(CS[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |
Structure |
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