Ki Summary

Reaction Details

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Target

Somatostatin receptor type 2

Ligand

BDBM50075279

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_200682

7.3±n/a nM

Citation

Pasternak, A; Pan, Y; Marino, D; Sanderson, PE; Mosley, R; Rohrer, SP; Birzin, ET; Huskey, SE; Jacks, T; Schleim, KD; Cheng, K; Schaeffer, JM; Patchett, AA; Yang, L Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett9:491-6 (1999) [PubMed]

More Info.:

Get all data from this article, Assay Method

Somatostatin receptor type 2

Name:

Somatostatin receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41344.94

Organism:

Homo sapiens (Human)

Description:

P30874

Residue:

369

Sequence:

MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCG
NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT
VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY
AGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI
RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVL
TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTL
LNGDLQTSI

BDBM50075279

n/a

Name

BDBM50075279

Synonyms:

(2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3,4-dichloro-benzyl)-2-oxo-imidazolidin-1-yl]-3-(1H-indol-3-yl)-butyramide | CHEMBL147092

Type

Small organic molecule

Emp. Form.

C27H31Cl2N5O4

Mol. Mass.

560.472

SMILES

C[C@H]([C@@H](N1CCN(Cc2ccc(Cl)c(Cl)c2)C1=O)C(=O)NC[C@H]1OC[C@H](N)CO1)c1c[nH]c2ccccc12 |wU:2.2,22.23,wD:25.27,1.0,(-.86,3.13,;-.83,1.59,;.5,.83,;1.83,1.6,;1.82,3.14,;4.49,3.17,;4.49,1.63,;5.84,.86,;7.16,1.65,;8.5,.88,;9.83,1.66,;9.81,3.2,;11.14,3.98,;8.47,3.96,;8.45,5.5,;7.15,3.17,;3.16,.84,;3.18,-.7,;.5,-.71,;2.05,-.71,;-.27,-2.04,;.47,-3.37,;-.3,-4.7,;.47,-6.04,;-.32,-7.37,;-1.86,-7.36,;-2.65,-8.68,;-2.61,-6,;-1.84,-4.69,;-2.16,.81,;-2.16,-.72,;-3.49,-1.5,;-4.82,-.73,;-6.15,-1.5,;-7.48,-.73,;-7.48,.81,;-6.15,1.58,;-4.82,.81,)|

Structure